4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylacetic acid
3,5,3',5'-Tetraiodo Thyroacetic Acid
CAS: 67-30-1
Molecular Formula: C14H8I4O4
4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylacetic acid - Names and Identifiers
| Name | 3,5,3',5'-Tetraiodo Thyroacetic Acid |
| Synonyms | tetraiodothyroaceticacid Liothyronine EP Impurity D Levothyroxine – Impurity D 3,3',5,5'-tetraiodo-thyroaceticaci 3,5,3',5'-Tetraiodo Thyroacetic Acid acide3,5,3',5'-tetraiodothyroacetique 3,5-diiodo-4-(4-hydroxy-3,5-diiodophenoxy)benzeneaceticacid 3,5-diiodo-4-(4-hydroxy-3,5-diiodophenoxy)-benzeneaceticaci 4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylacetic acid |
| CAS | 67-30-1 |
| EINECS | 200-649-1 |
| InChIKey | PPJYSSNKSXAVDB-UHFFFAOYSA-N |
4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylacetic acid - Physico-chemical Properties
| Molecular Formula | C14H8I4O4 |
| Molar Mass | 747.83 |
| Density | 2.727±0.06 g/cm3(Predicted) |
| Melting Point | 219-220 °C (decomp) |
| Boling Point | 544.8±50.0 °C(Predicted) |
| Solubility | acetone: soluble19.60 - 20.40mg/mL, clear, colorless (or faintly yellow to yellow) |
| Appearance | powder to crystal |
| Color | White to Yellow to Green |
| pKa | 3.98±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| MDL | MFCD00055932 |
4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylacetic acid - Risk and Safety
| Hazard Symbols | T+ - Very toxic |
| Risk Codes | 28 - Very Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | CY1585800 |
4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylacetic acid - Reference Information
| Biological activity | Tetrac (Tetraiodothyroacetic acid), a natural derivative of L-thyroxine (T4), is a thyroxine integrin receptor antagonist. Tetrac blocks the action of T4 and 3,5,3 '-triiodo-L-thyronine (T3) at the cell surface receptor of thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities. |
| Cell Line: | HT-29 and HCT116 cells HT-29 and HCT116 cells |
| Concentration: | 0.01, 0.1, 1 μM 0.1 μM |
| Incubation Time: | 0, 2, 4, 6 days 30 min |
| Result: | Induced anti-proliferation of K-RAS wild-type colorectal cancer cells. Inhibited constitutively activated ERK1/2, and this inhibition can remove by anti-integrin αvβ3 antibody pretreatment. Delayed the onset of ocular melanoma. Reduced the S-100 and integrin staining level in the B16F10 mice model. |
| Animal Model: | Wild-type male Balb/C mice aged 8 weeks are inoculated with 102B16F10 or B16LS9 cells |
| Dosage: | 35 μg per day |
| Administration: | P.o. (added to the drinking water) daily for 40 days |
Last Update：2024-04-10 22:29:15
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Product Name: Levothyroxine Impurity 4（Levothyroxine EP Impurity D） Visit Supplier Webpage Request for quotationCAS: 67-30-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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Product Name: 3,5,3’,5’-Tetraiodo Thyroacetic Acid Visit Supplier Webpage Request for quotationCAS: 67-30-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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